diff --git a/0002-Remove-dependency-on-non-standard-mock.patch b/0002-Remove-dependency-on-non-standard-mock.patch
new file mode 100644
index 0000000..e138743
--- /dev/null
+++ b/0002-Remove-dependency-on-non-standard-mock.patch
@@ -0,0 +1,42 @@
+From 1b7558ed4060acd4ca34a88c7b14ce7da2baab13 Mon Sep 17 00:00:00 2001
+From: "Kai A. Hiller" <V02460@gmail.com>
+Date: Tue, 14 Dec 2021 18:16:37 +0100
+Subject: [PATCH] Remove dependency on non-standard mock
+
+---
+ setup.py                                | 4 +---
+ tests/storage/test_background_update.py | 3 +--
+ 2 files changed, 2 insertions(+), 5 deletions(-)
+
+diff --git a/setup.py b/setup.py
+index 2c6fb9aac..bfca16727 100755
+--- a/setup.py
++++ b/setup.py
+@@ -119,9 +119,7 @@ CONDITIONAL_REQUIREMENTS["mypy"] = [
+ # Tests assume that all optional dependencies are installed.
+ #
+ # parameterized_class decorator was introduced in parameterized 0.7.0
+-#
+-# We use `mock` library as that backports `AsyncMock` to Python 3.6
+-CONDITIONAL_REQUIREMENTS["test"] = ["parameterized>=0.7.0", "mock>=4.0.0"]
++CONDITIONAL_REQUIREMENTS["test"] = ["parameterized>=0.7.0"]
+ 
+ CONDITIONAL_REQUIREMENTS["dev"] = (
+     CONDITIONAL_REQUIREMENTS["lint"]
+diff --git a/tests/storage/test_background_update.py b/tests/storage/test_background_update.py
+index d77c00150..542b70a1e 100644
+--- a/tests/storage/test_background_update.py
++++ b/tests/storage/test_background_update.py
+@@ -12,8 +12,7 @@
+ # See the License for the specific language governing permissions and
+ # limitations under the License.
+ 
+-# Use backported mock for AsyncMock support on Python 3.6.
+-from mock import Mock
++from unittest.mock import Mock
+ 
+ from twisted.internet.defer import Deferred, ensureDeferred
+ 
+-- 
+2.33.1
+
diff --git a/matrix-synapse.spec b/matrix-synapse.spec
index 71b2f97..bfbd1af 100644
--- a/matrix-synapse.spec
+++ b/matrix-synapse.spec
@@ -14,7 +14,7 @@
 
 Name:       matrix-%{srcname}
 Version:    %{ghversion}%{rcv}
-Release:    2%{?dist}
+Release:    1%{?dist}
 Summary:    A Matrix reference homeserver written in Python using Twisted
 License:    ASL 2.0
 URL:        https://github.com/matrix-org/%{srcname}
@@ -26,13 +26,13 @@ Source4:    synapse@.service
 
 # non-upstreamable patch to accept any version of python-cryptography, see RHBZ#1978949
 Patch1:     0001-relax-cryptography-dependency-version-requirement.patch
+Patch2:     0002-Remove-dependency-on-non-standard-mock.patch
 BuildArch:  noarch
 
 BuildRequires:  python3-devel
 BuildRequires:  python3-setuptools
 
 # Test dependencies
-BuildRequires:  python3-mock >= 2.0
 BuildRequires:  python3-parameterized >= 0.7.0
 BuildRequires:  /usr/bin/openssl
 
@@ -155,6 +155,9 @@ exit 0
 
 
 %changelog
+* Tue Dec 14 2021 Kai A. Hiller <V02460@gmail.com> - 1.49.0-1
+- Update to v1.49.0
+
 * Tue Nov 30 2021 Kai A. Hiller <V02460@gmail.com> - 1.48.0-1
 - Update to v1.48.0